Add an efficient bookkeeping professional to your team without having to devote another cubicle or office space with Microsoft Excel. Whether you want to simply add tools to aid your current bookkeeping staff or implement software that can relieve the burden of some fiscal processes, you can rely on Excel to help you run the numbers. To set up your first basic spreadsheet, click into a cell on the grid and type into it. You may want to make one spreadsheet that covers your accounts payable, receivable, investments, property, inventory, salaries and other things to track all in one, or devote a separate sheet for each. Once you set up your first spreadsheet you can use it as a template and create others from it.